Minoxidil is a medication used to treat hair loss. The exact mechanism by which minoxidil works is not fully understood, but it is believed to work by stimulating hair follicles to enter into the anagen phase, which is the growth phase of hair follicles. Minoxidil is a vasodilator, meaning that it widens blood vessels and increases blood flow to the hair follicles. This increased blood flow delivers more nutrients and oxygen to the follicles, which can help to promote hair growth. Minoxidil also appears to directly stimulate the hair follicles by prolonging the anagen phase of the hair growth cycle, and by increasing the size of hair follicles.
Not everyone who uses minoxidil will experience the same level of hair growth or regrowth. However, there are certain factors that may increase the likelihood of responding positively to minoxidil treatment.
One of the most important factors is the stage of hair loss. Minoxidil is most effective for individuals with early-stage hair loss or thinning. In particular, individuals with androgenetic alopecia (a common form of hair loss that is genetic and hormone-related) tend to respond well to minoxidil. Additionally, age can be a factor in minoxidil response. Individuals under the age of 40 tend to respond better to minoxidil than those over 40. Other factors that may influence minoxidil response include the duration of hair loss, the pattern of hair loss, and the extent of hair loss. Generally, individuals who have been experiencing hair loss for a shorter amount of time, who have a less extensive pattern of hair loss, and who have a smaller area of hair loss tend to respond better to minoxidil.
Genetics plays an important role in the minoxidil response. Minoxidil is a prodrug and needs to be activated into minoxidil sulphate by sulphotransferase. People with high sulphotransferase in the scalp will respond to minoxidil and those with less sulphotransferase enzyme will not respond to minoxidil for hair loss treatment. Minoxidil responders can be detected by the Minoxidil response test (MRT) first time introduced in India by a startup company Trichogene founded by Dr.M. Sai Babu and Mohd. Rizwan Younus.
MRT is very simple from a buccal swab sample we can detect whether a person is a responder to minoxidil or not with 100% accuracy by pharmacogenetic analysis.
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MRT saves a lot of time and money and also it provides valuable information to doctors to provide precision hair loss treatment.
